At the time of economic crisis periods, the two unlikely friends, the husky, but mentally retarded Lennie (John Malkovich) and caring George (Gary Sinise), their lives as migrant workers in California. Her dream is to one day own a own farm. Here, they make however some obstacles in the way. Your old job they had to flee because they were there accused of attempted rape. The good-hearted Lennie had a woman torn the dress, because he longs so much then to touch soft things. At her new job, the Tyler Ranch, both lie over backward and join her dream a little closer than Candy (Ray Walston), an old, one-armed farmworkers offered to merge his money with George and Lennie to a house buy. But Curley (Casey Sziemasko), the latter the son of her boss, the friends makes life difficult. One day a catastrophe occurs and George will be out before the hardest decision of his life.
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